Hydroxychloroquine induced cardiomyopathy a case report

Discussion in 'Aralen' started by jaa, 20-Mar-2020.

  1. Loko-fan User

    Hydroxychloroquine induced cardiomyopathy a case report


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    Details of chloroquine/hydroxychloroquine-induced cardiomyopathies case reports including histologic studies of the myocardium. The cumulative dose of CQ/HCQ 15–5040 g and the duration of treatment 2–31 years vary greatly. Our patient had the longest duration of treatment 35 years and one of the highest cumulative doses 3195 g. Hydroxychloroquine HCQ-induced cardiomyopathy is one of the rare but severe complications following prolonged HCQ use. However, the exact mechanism of HCQ cardiotoxicity remains unclear and it is difficult to identify risk factors. Clinical manifestations of antimalarial-induced cardiotoxicity can manifest as restrictive cardiomyopathy, dilated cardiomyopathy, or conduction abnormalities such as bundle branch and atrioventricular block. Patients usually present with HF symptoms. However, non-specific chest discomfort may be a presenting or coexisting feature.

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    Hydroxychloroquine induced cardiomyopathy a case report

    Hydroxychloroquine-induced cardiomyopathy in a patient., Hydroxychloroquine-induced cardiomyopathy and heart.

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  3. The recent clinical practice guidelines on the use of EMB highlight the following scenarios relevant to our case of HCQ-induced cardiomyopathy heart failure of 3 months associated third-degree heart block or failure to respond to usual care within 1-2 weeks class IIa, and heart failure associated with unexplained hypertrophic cardiomyopathy class IIb. 67 Electron microscopy is critical for the analysis of EMB specimens because conventional light microscopy is less sensitive and.

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    Retinal toxicity, neuromyopathy, and cardiac disease are recognized adverse effects of hydroxychloroquine. Immediate withdrawal of hydroxychloroquine is essential if toxicity is suspected because of the early reversibility of cardiomyopathy. Dec 21, 2016 Hydroxychloroquine HCQ is a widely used medication in the management of many connective tissue diseases. Cardiac toxicity is a rare but serious complication related to the chronic use of HCQ. Possible manifestations are the development of cardiomyopathy or of conduction abnormalities. Hydroxychloroquine induced myopathy is a rare side effect and reported prevalence is up to 6.7% 2. Involvements with respiratory musculature or myocardium were reported 3–5, but myopathy symptoms usually improve only after discontinuation of hydroxychloroquine 2.

     
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