Pharmacological treatment with chloroquine inhibits autophagy in vivo

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  1. sky_ User

    Pharmacological treatment with chloroquine inhibits autophagy in vivo


    Several cancer treatments stimulate the autophagic process and when autophagy is inhibited, cancer cells show an enhanced response to multiple treatments. These findings have nourished the theory that autophagy provides cancer cells with a survival advantage during stressful conditions, including exposure to therapeutics.

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    Originally applied as an antimalarial medication, the use of chloroquine or chloroquine derivatives to inhibitor autophagy is currently being explored as possible chemotherapeutic interventions for the treatment of cancer. Here, we have explored the possible beneficial effect of combining antiestrogen therapies with hydroxychloroquine HCQ for the treatment of antiestrogen resistant ER+ breast cancers. A number of in vitro 15,16,17,18,19 and in vivo 19,20,21,22 preclinical studies have shown that inhibiting autophagy enhances CRC cell death and could be used to restore chemosensitivity. Autophagy has been identified as a cellular process of bulk degradation of cytoplasmic components and its persistent activation is critically involved in the renal damage induced by ureteral obstruction. However, the role and underlying mechanisms of autophagy in hyperuricemic nephropathy HN remain unknown. In the present study, we observed that inhibition of autophagy by 3-methyladenine 3.

    In this review we examine two approaches to modulate autophagy as complementary cancer treatment: inhibition and induction. Therefore, interference with the autophagic response can potentially enhance the efficacy of cancer therapy.

    Pharmacological treatment with chloroquine inhibits autophagy in vivo

    Rapamycin and Chloroquine The In Vitro and In Vivo., Clarithromycin inhibits autophagy in colorectal cancer by.

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  3. Aug 30, 2018 Clinical trials with chloroquine—a known autophagy inhibitor—were unable to achieve complete autophagy inhibition in vivo, warranting the search for more potent autophagy inhibitors.

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    Pancreatic ductal adenocarcinoma PDAC is characterized by KRAS- and autophagy-dependent tumorigenic growth, but the role of KRAS in supporting autophagy has not been established. We show that, to our surprise, suppression of KRAS increased autophagic flux, as did pharmacological inhibition of its effector ERK MAPK. Autophagy is a catabolic process through which eukaryotic cells degrade disposable, ectopic or damaged cytoplasmic material. The inhibition or hyperactivation of autophagy has been linked to the. Cell culture experiments, pharmacological inhibition is more kinetically controllable, and is the most frequently employed strategy for both in vitro and in vivo studies. The most widely employed chemicals that inhibit the last stage of autophagy are chloroquine CQ, bafilomycin A 1 BafA 1, and lysosomal protease inhibitor cocktails 11.

     
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