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    Restless legs syndrome (RLS) is characterized by unpleasant sensations of the legs that are worse in the evening and at night, and that are relieved by movement. Most patients with RLS also have movements of the legs that occur periodically at 20- to 30-second intervals for minutes to hours during sleep. Although the term nocturnal myoclonus sometimes is used to describe these movements, they usually are not sudden lightning-like movements. Rather, they typically last for about 1 second and consist of extension of the great toe with variable degrees of ankle extension, knee extension, and hip extension or flexion. PLMS (previously called nocturnal myoclonus) is a disorder in which repetitive, brief, and stereotyped limb movements occur during sleep, usually about every 20 to 40 seconds. Dorsiflexions of the big toe, ankle, knee, and sometimes the hip are involved. Periodic movements occur during sleep but the unpleasant evening and nighttime sensations are absent. Successful clonidine treatment of restless leg syndrome Cozaar Blood Pressure Parameters - Cozaar Brochure Restless Legs Syndrome - Journal of the American Board of Family.
     
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