Is it possible for it to work quicker in some people? I've heard it can take months, but I must say that I haven't felt like this since I was a kid - not achy or stiff. Chloroquine volume of distribution Can plaquenil cause edema Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. It does not work against certain. I'd like to report that I never have symtoms or flares anymore, but I do, but I think the Plaquenil makes the difference between being a sick person pre-plaquenil and a normal person who occationally feels sick. I was able to function again, as in go to work, after about a year and a half. My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? I know I've read it can take up to 6 months but what I'm wondering is, do you just wake up one day and find it's kicked in 6 months down the road or more likely, it starts to work slowly over 6 months? It takes anywhere from 4-6 months before the affects of Plaquenil are seen/felt. Has anyone had a similar experience with Plaquenil? - Sko Just an FYI- Plaquenil is NOT known to start working that fast. How many hours does plaquenil work Plaquenil - FDA prescribing information, side effects and uses, Plaquenil.long do I have to wait? DailyStrength Chloroquine classificationHydroxychloroquine creamHow much is chloroquine in the usPlaquenil visual field testing Re Plaquenil - Can It Work Quickly? I tried to get on Plaquenil years ago, and couldn't tolerate it, but now I'm thinking there might be a lessor dose I should try. I'm new to the area, so don't have a rheumy yet. Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly?. How long did Plaquenil/Hydroxychloroquine take? DailyStrength. Plaquenil Tablets - Medsafe. I do think you should let your rheumy know. It seems to me in Dr. Wallace's book and from other folks on this forum, that when there was trouble when first starting Plaq, they were taken off for a few days and then restarted at half the dose for awhile, building up to the full dose. It seems to work for many. Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. In the same study, the plasma peak concentration was. 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 hours 123.5 days. Urine Aug 11, 2019 If you are an active lupus flare, you will need to take prednisone and/or an NSAID to bridge the gap until Plaquenil begins to work. The normal range of time that it takes to work is between 1–3 months most people say 60 days Personally, I feel relief after about 14 days and then no additional improvements until the three month mark.