Chloroquine retinopathy mechanism

Discussion in 'Canada Drugs Online' started by Antihit, 17-Mar-2020.

  1. sai_t Well-Known Member

    Chloroquine retinopathy mechanism


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

    Rheumatoid arthritis treatment plaquenil mono Hydroxychloroquine dosage for osteoarthritis Chloroquine exoerythrocytic H-chloroquine

    Mechanisms of retinal damage in chloroquine retinopathy. Article in Russian Ivanina TA, Lebedeva MN, Sakina NL, Babizhaev MA, Ermakova VN. The paper presents the results of comparative electron microscopic, electrophysiological and biochemical studies of chloroquine effect on lipid peroxidation LPO both in vitro and in vivo rabbits and. The mechanism of action of these drugs remains uncertain but includes effects on the function of lysosomes and components of the immune system. 1,2. It was hoped that the chemical modification of chloroquine to hydroxychloroquine would abrogate its retinal toxicity. Chloroquine and its derivative, hydroxychloroquine sulfate, which have been useful in treating malaria and in larger doses, collagen-vascular disease, cause a cumulative dose-related pigmentary retinopathy. Mechanism. Inhibition of critical enzymes & interference with the metabolic functions of retinal pigment epithelium RPE & photoreceptors.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Chloroquine retinopathy mechanism

    Chloroquine Retinopathy - an overview ScienceDirect Topics, Retinal Toxicity Associated With Hydroxychloroquine and.

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    • Recommendations on Screening for Chloroquine and..
    • Drug induced maculopathy - EyeWiki.
    • Chloroquine retinopathy - Wikipedia.

    Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Disease EntityDiagnosisManagementAdditional ResourcesReferences

     
  7. vermut Moderator

    Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Ask the Expert Plaquenil and Sjögren’s Taking Plaquenil for Rheumatoid Arthritis Plaquenil Retinotoxicity Updated Guidelines
     
  8. Semenek New Member

    Plaquenil Concordia Pharmaceuticals Inc. FDA Package Insert Pharmacokinetics Following a single 200 mg oral dose of PLAQUENIL to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days.

    Hydroxychloroquine - Wikipedia
     
  9. smaragd_irina New Member

    My Take on New Ocular Screening Guidelines for Plaquenil. I am lucky as a rheumatologist in practice for more than 30 years to have only had one malpractice lawsuit. But it was for alleged Plaquenil related eye toxicity, and believe me, attornies will grab any guideline they can as "Standard-of-Care" if it suits their case. All to say, we treat patients, not guidelines, but we all need to aware of these.

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