It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Long term plaquenil therapy Plaquenil skin rash symptoms Plaquenil Hydroxychloroquine may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. The mechanisms underlying the anti-inflammatory and immunomodulatory effects of PLAQUENIL are unknown. Medication Guide. PATIENT INFORMATION. Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Common side effects include vomiting, headache, changes in vision and muscle weakness. Severe side effects may include allergic reactions. It does not appear to be safe during Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Plaquenil anti inflammatory mechanism Effects of chloroquine on viral infections an old drug., Hydroxychloroquine - Wikipedia Long term effects of plaquenilChloroquine phosphate chemical structureMissed dose of plaquenil With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Hydroxychloroquine Plaquenil. How to Succeed in Plaquenil Screenings. Many anti-inflammatory medications used for rheumatoid arthritis have been applied to inflammatory bowel disease IBD therapy. Hydroxychloroquine Plaquenil® has received little attention in Crohn’s disease CD. 1 This anti-malarial agent is an older disease-modifying anti-rheumatic drug and is used by rheumatologists for patients who try and fail or fear trying immunomodulator and biologic therapy. Mechanism of action The mechanisms underlying the anti-inflammatory and immunomodulatory effects of Plaquenil are unknown. Indications and Usage for Plaquenil Malaria. Plaquenil is indicated for the treatment of uncomplicated malaria due to P. falciparum, P. malariae, P. ovale, and P. vivax. Exclusion criteria for this study included treatment with hydroxychloroquine, corticosteroids, non-steroidal anti-inflammatory drugs NSAIDs or immunosuppressive drugs in the three months before the study. No patient had any ophthalmological contraindications for the use of hydroxychloroquine nor any apparent oral infection.