In a large, case-control study of elderly patients, those who used corticosteroids and NSAIDs concurrently had an estimated relative risk (RR) for peptic ulcer disease and GI hemorrhage of 14.6 compared to those who used neither. Oral corticosteroid use was associated with a doubling of the risk (estimated RR = 2.0), but the risk was confined to those who also used NSAIDs. Chloroquine class of drug Can plaquenil cause yeast infections Chloroquine phosphate eye drops If patients achieved remission after 4 months, they were considered to be in early remission and could taper prednisone down to zero. If they were still in remission after eight months, they could also taper and ultimately stop taking methotrexate. If remission was lost after eight months, prednisone was restarted at a low dose of 7.5 mg/day. The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. Sjogren's Syndrome Hydroxychloroquine - Painful Muscles Of Legs. I have been on 400mg of Plaquenil for 7 months now, but for the last 2 months I have been experiencing muscle problems in my legs, it is so painful that I am yelling out with pain. I stopped taking the Plaquenil and the muscle problems stopped. MANAGEMENT: Caution is advised if oral corticosteroids and NSAIDs are used together, especially in patients with a prior history of peptic ulcer disease or GI bleeding and in elderly and debilitated patients. It is possible that both categories of agents are ulcerogenic and have additive effects on the GI mucosa during coadministration. Some investigators have also suggested that the primary effect of corticosteroids in this interaction is to delay healing of erosions caused by NSAIDs rather than cause de novo ulcerations. Can i take prednisone and hydroxychloroquine together Prednisone/Plaquenil question -, Prednisone and Plaquenil DailyStrength Plaquenil and pain reliefHydroxychloroquine sulfate 200 mg couponChloroquine dose during pregnancy I started taking prednisone for several weeks along with 400 mg of hydroxychloroquine. Within two month my skin was clear. After another two months on the drug I experienced serious headaches and. Hydroxychloroquine Reviews Everyday Health. Autoimmune Diseases Prednisone And Hydroxychloroquine 200 Mg?. Can i take advil with Prednisone and / or Plaquenil. Drug interactions are reported among people who take Prednisone and Plaquenil together. This study is created by eHealthMe based on reports of 13,794 people who take Prednisone and Plaquenil from Food and Drug Administration FDA, and is updated regularly. On eHealthMe, you can evaluate side effects and drug interactions from 16 million FDA. By Connie Rifenburg June 3, 2015 at pm. Ang, I had hair loss pretty severe when I first started on Prednisone, Plaquenil, and Methotrexate. I guess it may depend on the dosage, and hopefully your hair loss will stop as mine did after a few months. I wait at least 20 minutes and take 20 mg of Prilosec then eat more cereal/crackers and take the 7.5 Meloxicam. I take the second 7.5 after dinner. The doctor also has me on Vit D/Calcium as prolonged use of Prednisone can contribute to the development of steroid-induced osteoporosis.