Alternatively, we suggest using this opportunity to take a little break from work and read some of the interesting articles below. Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Side effect plaquenil eyes Plaquenil maculopathy images Non-small cell lung cancer NSCLC is a type of malignant cancer, and 85% of metastatic NSCLC patients have a poor prognosis. C2-ceramide induces G2/M phase arrest and cytotoxicity in NSCLC cells. In this study, the autophagy-inducing effect of C2-ceramide was demonstrated, and cotreatment with the autophagy inhibitor chloroquine CQ was investigated in NSCLC H460 and H1299 cells. The results. Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. Chloroquine lung cancer Chloroquine supplementation increases the cytotoxic effect of., Chloroquine and hydroxychloroquine for cancer therapy Malaria egypt chloroquine or mefloquinePlaquenil 200 mg brchChloroquine dna mobilityCheap aralen 250Hydroxychloroquine chest x ray Mar 02, 2013 New therapies are urgently needed for patients with small cell lung cancer SCLC. Chemotherapy and targeted therapies, including the Bcl-2 inhibitor ABT-737, may induce tumor cell autophagy. Autophagy can promote survival of cancer cells under stress. Combination treatment with ABT-737 and chloroquine in.. NCI Drug Dictionary - National Cancer Institute. Chloroquine potentiates the anti-cancer effect of lidamycin.. To investigate if the ability of pCQ to inhibit cancer cell migration and invasion in vitro translates into decreased metastasis in vivo, we used an experimental lung metastasis model of the 4T1 breast cancer. In this model, cancer cells are injected intravenously i.v. to colonize the lung and form lung metastasis. The studies we included evaluated the treatment agents in various types of cancer with different etiologies and disease course. Different types of cancer may have some effect on the results of this meta-analysis. Two inhibitors chloroquine or hydroxychloroquine were evaluated in all cancer types. It may be different in different cancer types. Apr 11, 2012 Chloroquine as an Anti-autophagic Radiosensitizing Drug in Stage I-III Small Cell Lung Cancer Chloroquine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.