Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Tramadol and plaquenil Chloroquine cas Highlights of the 2016 guidelines include the following. Use real body weight. “The bottom line is that the daily dose should be 5.0 mg per kg or less, using real body weight,” said Michael F. Marmor, MD, at Stanford University in Palo Alto, Calif. Purpose The 2016 guidelines by the American Academy of Ophthalmology AAO on screening for Hydroxychloroquine HCQ retinopathy HCQR recommend the use of ancillary testing, including Fundus. The new guidelines recommend 10-2 automated perimetry, plus at least one of SD-OCT, FAF, or mfERG if they are available. These tests should be performed at baseline and at each subsequent evaluation. Other tests may be considered as well, but are generally insufficiently sensitive to detect early evidence of hydroxychloroquine toxicity. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil guidelines aao 2016 How to Succeed in Plaquenil Screenings, Detection of Hydroxychloroquine toxicity based on AAO 2016. Plaquenil for lupus nephritisIcd 10 plaquenil ophthalmologyCan plaquenil cause kidney disease Twenty-seven percent of cases of hydroxychloroquine retinopathy in obese women had ostensibly safe dosing based on 2016 AAO guidelines. Overdosing of obese women by 2016 AAO guidelines is not rare. Daily dosing based on the older 6.5-mg/kg ideal weight threshold is safer in women with a body mass index of 30 kg/m 2 or more. The 2016 American Academy of Ophthalmology Hydroxychloroquine.. New Screening Guidelines for Hydroxychloroquine Toxicity. Hydroxychloroquine dosing guidelines have little impact in.. Do you know the current screening recommendations for patients on Plaquenil? Which tests should you choose and when? Risk factors for toxicity are high dose, long duration, renal disease and tamoxifen. If you are coming to the OA July Scientific Meeting July 29th Red Hill, you will hear more about Plaquenil toxicity. Thereafter, the AAO states annual screening can be deferred until year 5 on the medication but should start sooner if the patient is at a higher risk for toxicity. The guidelines recommend 1 an automated visual field as well as a 2 spectral-domain optical coherence tomography SD OCT. Recommendations by the AAO to limit HCQ dosing to 6.5 mg/kg of ideal body weight have been 31 revised to 5 mg/kg of actual body weight 5. Some authors recommend 6.5 mg/kg of actual 32 body weight with a cap at 400 mg per day and further adjustments for renal insufficiency 10.