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    [Posted 08/03/2018]AUDIENCE: Patient, Health Professional, Oncology ISSUE: The antibiotic azithromycin (Zithromax, Zmax) should not be given long-term to prevent a certain inflammatory lung condition in patients with cancers of the blood or lymph nodes who undergo a donor stem cell transplant. Results of a clinical trial found an increased rate of relapse in cancers affecting the blood and lymph nodes, including death, in these patients. We are reviewing additional data and will communicate our conclusions and recommendations when our review is complete. BACKGROUND: The serious lung condition for which long-term azithromycin was being studied called bronchiolitis obliterans syndrome is caused by inflammation and scarring in the airways of the lungs, resulting in severe shortness of breath and dry cough. Cancer patients who undergo stem cell transplants from donors are at risk for bronchiolitis obliterans syndrome. The manufacturer of brand name azithromycin is providing a Dear Healthcare Provider letter on this safety issue to health care professionals who care for patients undergoing donor stem cell transplants. Azithromycin is not approved for preventing bronchiolitis obliterans syndrome. Zithromax - Uses, Side Effects, Interactions - Zithromax Oral Uses, Side Effects, Interactions, Pictures, Warnings. Azithromycin antibiotic to treat bacterial infections - NHS
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    They belong to different classes and have different mechanisms of action. While they both have broad spectrum activity against various gram-positive and gram-negative bacteria, some resistance has developed to both drugs. The choice of which antibiotic to use will be made by the treating doctor according to the illness, organism causing it, and susceptibility of the organism. While both antibiotics fight bacterial infections, the way in which they do that differs. Doxycycline belongs to the class of drugs called tetracyclines, which work by interfering with protein synthesis of the bacteria, thus not allowing the organism to replicate. It is referred to as a bacteriostatic agent, which means that it stops the bacteria from multiplying. The body's immune system kills off the bacteria already there. Doxycycline vs. Tetracycline - MedicineNet Doxycycline - Antibiotic Drugs, Information, Description on Doxycycline.
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