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    Indikasjoner | Dosering | Kontraindikasjoner | Forsiktighetsregler | Interaksjoner | Graviditet, amming og fertilitet | Bivirkninger | Overdosering / Forgiftning | Egenskaper | Pakninger, priser og refusjon: Voksne: Vanlig startdose er 80 mg pr. Dosen økes deretter til vanlig vedlikeholdsdose: 40-60 mg 3 ganger daglig. Eldre bør ha en døgndose Norsk legemiddelhåndbok: Forslag til nedtrapping og seponering Interaksjonsanalyse av legemiddellisten anbefales før seponering. Influence of debrisoquin phenotype on the inducibility of propranolol metabolism. Kan også kombineres med andre : Voksne: Initialt 10 mg 3-4 ganger daglig. Barn og ungdom: Dosering bør bestemmes individuelt og følgende er kun veiledende: 0,25-0,5 mg/kg 3-4 ganger daglig, som justeres etter respons. Migreneprofylakse: Voksne: Startdose 20 mg 3 ganger daglig i 1 uke. Før hver dosejustering bør behandlingen pågå 1-3 uker for å sikre at det nye blodtrykksnivået har stabilisert seg. Vedlikeholdsbehandling: 160 mg daglig fordelt på 2-3 enkeltdoser. Sekundærprofylakse etter : Voksne: Behandlingsstart bør skje innen 3 uker med 40 mg 4 ganger daglig. Benign essensiell tremor: Voksne: Startdose 20 mg 2-3 ganger daglig. Opphør av interaksjoner ved seponering kan gi økt/redusert virkning av gjenværende legemidler. Bruk av betablokkere kan utløse eller forverre hjertesvikt og obstruktiv lungesykdom. Dosetilpasning Dosebehovet av propranolol vil være inntil 3-5 ganger høyere i kombinasjon med fenobarbital. Ved hjertesvikt må myokardets kontraktilitet opprettholdes og svikten kompenseres. Interaksjonsgrad vil kunne variere mye og kombinert bruk krever nøye klinisk oppfølging og ytterligere dosejustering ved behov. Legemiddelalternativer Metabolismen av andre betablokkere forventes å bli påvirket i mindre grad av fenobarbital. Pasienter med nedsatt kontraksjonskraft, særlig eldre, må undersøkes regelmessig mht. Betablokkere kan brukes med forsiktighet ved kompensert hjertesvikt. Det finnes flere antiepileptika som ikke induserer CYP3A4 (f. lamotrigin, gabapentin og valproat), men indikasjonsområde og dokumentasjon kan være annerledes. Generic Clonidine - children, effects, therapy, withdrawal, drug, person, people. The Diagnosis and Treatment of Baroreflex Failure NEJM
     
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