Chloroquine and cancer stem cells

Discussion in 'Canadian Online Pharmacy' started by Lawyerzxc, 22-Feb-2020.

  1. Twerny XenForo Moderator

    Chloroquine and cancer stem cells


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    The cancer cells in the study ended up being highly sensitized to some of these agents, for example Vitamin C 4-10 x more sensitive, Berberine and Chloroquine. It's noteworthy that, following Docycycline treatment, cells became sensitive to Vitamin C at a dosage level which is reachable orally IC-50 = within the range of 100uM - 250 uM. Up until recently, inhibitory effects of chloroquine on the late stage of autophagy was thought to be the major mechanism underlying cancer cells death from chloroquine. However, recent research provided compelling evidence that autophagy-inhibiting activities of chloroquine are dispensable for its ability to suppress tumor cells growth. CQ effects on cancer stem cells. Although conventional cancer treatment approaches reduce tumor mass/volume, they often fail to eradicate all tumor cells. 179 The major reason for treatment failure is related to tumor heterogeneity. 180 It has been proposed that cancer stem cells CSC or cancer‐initiating cells CIC with self‐renewal.

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    Chloroquine and cancer stem cells

    Autophagy, cancer stem cells and drug resistance - Smith., Frontiers Re-purposing Chloroquine for Glioblastoma.

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  3. Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions Author links open overlay panel Alejandro Vazquez-Martin a b Eugeni López-Bonetc b c Sílvia Cufí a b Cristina Oliveras-Ferraros a b Sonia Del Barco b d Begoña Martin-Castillo b e Javier A. Menendez a b

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    • PDF Chloroquine Targets Pancreatic Cancer Stem Cells via..

    Triple negative breast cancer TNBC is known to contain a high percentage of CD44 + /CD24 −/low cancer stem cells CSCs, corresponding with a poor prognosis despite systemic chemotherapy. Chloroquine CQ, an antimalarial drug, is a lysotropic reagent which inhibits autophagy. The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair. Author links open overlay panel Diana H. Liang a b 1 Dong Soon Choi b c 1 Joe E. Ensor b c Benny A. Kaipparettu d Barbara L. Bass a Jenny C. Chang b c. Chloroquine eliminates pancreatic cancer stem cells In an effort to identify more effective treatments against pancreatic CSCs, we established a novel low-throughput drug-screening platform for identifying compounds targeting CSCs unpublished observations; Irene Miranda-Lorenzo.

     
  4. sedoy1986 New Member

    Hydroxychloroquine and chloroquine are medications traditionally prescribed to prevent or treat malaria infections. Hydroxychloroquine Plaquenil Success, Reviews and Side Effects Malaria Treatment and Prevention Everyday Health Compare Plaquenil vs Chloroquine -
     
  5. ultrabyte User

    Hydroxychloroquine is in a class of drugs called antimalarials. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. PLAQUENIL® - Food and Drug Administration Plaquenil hydroxychloroquine sulfate dose, indications.
     
  6. idolshop New Member

    Chloroquine Dosage Guide with Precautions - Kg or more 1 g chloroquine phosphate 600 mg base orally as an initial dose, followed by 500 mg chloroquine phosphate 300 mg base orally after 6 to 8 hours, then 500 mg chloroquine phosphate 300 mg base orally once a day on the next 2 consecutive days Total dose 2.5 g chloroquine phosphate 1.5 g base in 3 days Less than 60 kg

    Coronavirus Antimalarial drug Chloroquine reportedly.