Prophylaxis for malaria in chloroquine resistant area

Discussion in 'Canadian Pharmacy Drugs Online' started by found, 18-Mar-2020.

  1. A1daris Well-Known Member

    Prophylaxis for malaria in chloroquine resistant area


    Begin 1-2 days before travel, daily during travel, and for 7 days after leaving. 500 mg chloroquine phosphate (300 mg base) orally on the same day each week Comments: -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate (600 mg base) may be taken orally in 2 divided doses, 6 hours apart.

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    Gozal D, Hengy C, Fadat G. Prolonged malaria prophylaxis with chloroquine and proguanil chloroguanide in a nonimmune resident population of an endemic area with a high prevalence of chloroquine resistance. Antimicrob Agents Chemother. 1991 Feb; 35 2373–376. PMC free article White NJ, Watt G, Bergqvist Y, Njelesani EK. Chloroquine is the drug of choice for people travelling to areas with chloroquine-sensitive malaria chloroquine-resistant malaria is widespread. Chloroquine Is available as a syrup or tablets and usually taken as a single dose once a week, on the same day each week. Prevention of Malaria. Malarone is indicated for the prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported. Treatment of Malaria. Malarone is indicated for the treatment of acute, uncomplicated P. falciparum malaria. Malarone has been shown to be effective in regions where the drugs.

    Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas. -Suppressive therapy should continue for 8 weeks after leaving the endemic area.

    Prophylaxis for malaria in chloroquine resistant area

    Prophylaxis of Malaria - PubMed Central PMC, Malaria prophylaxis - NICE CKS

  2. Chloroquine resistance wiki
  3. In areas where there is chloroquine-resistant malaria, either atovaquone/proguanil Malarone, mefloquine Lariam or doxycycline can be used for prophylaxis. Primaquine is a good alternative, but requires a G-6-PD screening blood test.

    • Malaria Travel & Health Guide, 2019 Online Book.
    • Malarone - FDA prescribing information, side effects and uses.
    • Malaria Prevalance in Indonesia - Prevention and Treatment - Health and..

    Areas with Malaria Drug Resistance 2 Malaria Species 3 Recommended Chemoprophylaxis 4 Key Information Needed and Helpful Links to Assess Need for Prophylaxis for Select Countries; Cambodia Present throughout the country, including Siem Reap city. None in the city of Phnom Penh or at the temple complex at Angkor Wat. Chloroquine Mefloquine. P. Current Views on Malaria Prophylaxis A Review Article. Dr Arlene Goldman MRCPUK MACP The development of resistance to familiar anti-malarials has created confusion both for Doctors and travellers as to what is the best and most effective anti-malarial to take and which areas of the World require special precautions. Several medications are available for malaria prophylaxis. When deciding which drug to use, clinicians should consider the specific itinerary, length of trip, drug costs, previous adverse reactions to antimalarials, drug allergies, and medical history. For a thorough discussion of malaria and guidance for prophylaxis, see Chapter 4, Malaria.

     
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  6. as26 Guest

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