The reaction can be phototoxic and/or photoallergic. Phototoxic reactions result from direct damage to tissue caused by light activation of the photosensitising agent, whilst photoallergic reactions are a cell-mediated immune response in which the is the light-activated photosensitising agent. Plaquenil side effects stomach pain High cost of hydroxychloroquine Plaquenil throat pain I've read on medical sites that Hydroxychloroquine can react with the sun causing allergic reactions and I wonder if this is the cause of the rash on this occasion or whether it's just my normal photosensitivity. I've read some posts on the forum here about people reacting to Hydroxychloroquine but it seems to be very severe as you say twitchytoes. If photosensitivity is a problem for you, here are some ways to protect yourself from the sun Be Sun Smart With Lupus. If you are photosensitive, the best rule is to avoid midday and tropical sun. Plaquenil is generally agreed to reduce photosensitivity a little, so that it is an extra help, but not so much that other precautions can be relaxed. In a very few people it can cause a photosensitive reaction, by a different sort of mechanism, which cancels out the protective element. Although some oral photosensitising medications can cause photoallergic reactions, most cause phototoxic reactions. Photoallergic reactions occur less commonly than phototoxic reactions and are mostly caused by photosensitising topical agents. Plaquenil and photosensitivity Lupus and Sun Exposure, Lupus Photosensitivity and UV Light Stopping plaquenil medicationChloroquine and proguanil buy onlineTraitement lucite plaquenilVisual prolem with plaquenilChloroquine phosphate injection bp Once we determined that Plaquenil was worsening my psorasis to affect my nails and tendon inserts, I came off it for good. Skin rashes occasionally develop and hydroxychloroquine may make you more sensitive to the sun, so it is advisable to use the usual precautions of sunscreens and a hat if you are in the sun. Plaquenil and the sun - Sarcoidosis - Inspire. Photosensitivity -. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. The malaria medication hydroxychloroquine Plaquenil may ease the symptoms of some types of sun allergies. Therapy. If you have a severe sun allergy, your doctor might suggest gradually getting your skin used to sunlight each spring. Drug-induced photosensitivity occurs when certain photosensitising medications cause unexpected sunburn or dermatitis a dry, bumpy or blistering rash on sun-exposed skin face, neck, arms, backs of hands and often lower legs and feet. The rash may or may not be itchy. Both Sjogren's and Plaquenil can increase skin sensitivity to sunlight. There are other medications that can cause photosensitivity too. I never used to burn.