One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil and ra Does plaquenil reduce spleen inflammation Plaquenil similar Plaquenil and stem cell injection If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. What Drusen Deposits. Objective To determine the distributions of basal laminar and basal linear deposits in Bruch membrane BM with respect to age and early age-related maculopathy ARM. Methods The foveas of 41 human eyes 60 years n=9; ≥60 years n=32, preserved no later than 3.5 hours post mortem, were examined using light and electron microscopy. The drusen-like deposits were located in a ring-shaped distribution between the retinal pigment epithelium and Bruch's membrane, with the majority of eyes having macular sparing. In patients with glomerulonephritis, the drusen-like deposits were more numerous than in those systemic lupus erythematosus patients without renal involvement. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil drusen deposits Macular degeneration and lupus" Lupus Community., Basal Linear Deposit and Large Drusen Are Specific for. What are similar drugs to plaquenilPlaquenil ocular side effectsKeyhole hydroxychloroquineHydroxychloroquine plaquenil side effects Both medications can cause corneal deposits, posterior subcapsular lens opacity, ciliary body dysfunction, and most important, irregularity in the macular pigmentation in the early phase, a ring of macular pigment dropout in the advanced stage, and peripheral bone spicule formation, vascular attenuation, and optic disc pallor in the end-stage. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. Drusen-Like Deposits Common in Young Adults With Systemic.. Plaquenil Toxicity - OCTMD. They found a high incidence of drusen in 14 out of 55 people with Alzheimer's, compared to two out of 48 people without Alzheimer’s. Deposits. Drusen are small deposits of fat, proteins and minerals, including calcium and phosphate deposits that form in a layer underneath the retina. Basal Laminar Drusen. Basal laminar drusen is a condition in which yellow round deposits of lipid waste accumulate between the base of the retinal pigment epithelium and Bruch's membrane in the outer retina. These lesions appear in young adulthood as opposed to the drusen of age related macular degeneration which develop in late life. Drusen, from the German word for node or geode singular, "Druse", are tiny yellow or white accumulations of extracellular material that build up between Bruch's membrane and the retinal pigment epithelium of the presence of a few small "hard" drusen is normal with advancing age, and most people over 40 have some hard drusen. However, the presence of larger and more numerous drusen.