Chloroquine mechanism of action autophagy

Discussion in 'Chloroquine 150 Mg' started by DAKrules, 21-Feb-2020.

  1. Meow Guest

    Chloroquine mechanism of action autophagy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    In parallel with these findings, another study demonstrated that autophagy is a key mechanism for anti-leukemic effects of ATO in AML cell lines and leukemic progenitors from AML patients, and this induction of autophagy flux is associated with mitogen-activated protein kinase kinase MEK/extracellular signal-regulated kinase ERK-dependent autophagic cell death. An important mode of action of chloroquine and hydroxychloroquine is the interference of lysosomal activity and autophagy. It is widely accepted that chloroquine and hydroxychloroquine accumulate. Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of action autophagy

    Autophagy Modulation in Cancer Current Knowledge on., Mechanisms of action of hydroxychloroquine and chloroquine.

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  3. Jan 27, 2010 Chloroquine CQ, an antimalarial lysosomotropic agent, has been identified as a potential adjuvant in the treatment regimen of GBMs. However, the mechanism of CQ-induced tumor cell death is poorly defined. We and others have shown that CQ-mediated cell death may be p53-dependent and at least in part due to the intrinsic apoptotic death pathway.

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    Chloroquine has a long history of human use and is currently being tested as a sensitizing agent for certain cancers, making understanding its mechanisms of action both topical and important. Chloroquine is a lysosomotropic weak base, which in the monoprotonated form diffuses into the lysosome, where it becomes diprotonated and becomes trapped. Autophagy is involved in the pathophysiology of numerous diseases and its modulation is beneficial for the outcome of numerous specific diseases. Several lysosomal inhibitors such as bafilomycin A1 BafA1, protease inhibitors and chloroquine CQ, have been used interchangeably to block autophagy in in vitro experiments assuming that they all primarily block lysosomal degradation. Autophagy inhibition by chloroquine increased AVOs accumulation, decreased MMP and consequently increased ROS. Chloroquine pre-treatment also sensitized different cancer cells towards artemisinin. Abstract

     
  4. torrentilla Moderator

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine MedlinePlus Drug Information Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs. Common and Rare Side Effects for Hydroxychloroquine Oral
     
  5. s-box023 Well-Known Member

    Side Effects of Aralen Chloroquine, Warnings, Uses Our Aralen chloroquine phosphate Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

    CHLOROQUINE PHOSPHATE TABLETS BP 250MG
     
  6. Anvil XenForo Moderator

    Methotrexate and plaquenil - Dec 15, 2010 hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works.

    Plaquenil Hydroxychloroquine - Side Effects, Dosage.