Antimalarials are usually given as one or two pills, once a day. Side effects include vision changes (blurring, halos around lights and sensitivity to light), headache, dizziness, nausea and vomiting. Individuals taking an antimalarial should have eye examinations periodically. Chloroquine autophagy off target Plaquenil causes leg weakness in psoriatic arthritis Chloroquine interaction This is a case where Plaquenil likely triggered new-onset psoriasis in a patient who was genetically susceptible. There are several other drugs that would likely be beneficial for both diseases by virtue of their anti-inflammatory or immunosuppressive effects, namely, acitretin Soriatane. The incidence of new-onset or flaring psoriasis associated with Plaquenil varies from 0-100% depending on which case series report you read! Allergic and psoriasis-like rashes tend to develop within the first few weeks or months of starting Plaquenil. If Plaquenil helps a serious chronic disease such as lupus, it may be taken for years. What Is Plaquenil? Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. What Are Side Effects of Plaquenil? The use of Plaquenil may cause a severe flare of psoriasis. Unless you are directed to do so by your doctor, do not take Plaquenil, the most commonly prescribed antimalarial. Plaquenil causing psoriasis Hydroxychloroquine Plaquenil Side Effects & Dosage for., Plaquenil Use in Autoimmune Diseases Plaquenil for cfs Anti-malarials. Sometimes used to treat lupus and rheumatoid arthritis, Atabrine quinacrine, Aralen Phosphate chloroquine, and Plaquenil hydroxychloroquine may cause a flare of psoriasis. Medications That Can Trigger Psoriasis - Psoriasis Center.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Rx Side Effects New Plaquenil Guidelines and More - American.. Psoriasis or porphyria as these conditions may be exacerbated by its use. Observe caution in patients with psoriasis. PLAQUENIL may cause acute generalized exanthematous pustulosis AGEP. AGEP has to be distinguished from psoriasis, although PLAQUENIL may precipitate attacks of psoriasis. It may be associated with fever and hyperleukocytosis. Hypoglycemia Plaquenil has been shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with or without antidiabetic medications see DRUG INTERACTIONS and ADVERSE REACTIONS. Patients treated with Plaquenil should be warned about the risk of hypoglycemia and the associated clinical signs and symptoms. To make sure Plaquenil is safe for you, tell your doctor if you have a history of vision changes or damage to your retina caused by an anti-malaria medication; heart disease, heart rhythm disorder such as long QT syndrome; diabetes; a stomach disorder; an allergy to quinine; liver or kidney.