It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Plaquenil and iron Plaquenil ara Mar 20, 2008 Has anyone ever questioned or compared the efficacy of Plaquenil versus a generic Hydroxychloroquine formulation? Is there any way to verify that the medications being purchased through my local pharmacy are not counterfit? Answer. The active ingredient of brand name Plaquenil and generic hydroxychloroquine are the same. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Hydroxychloroquine HCQ, is a 4-aminoquinoline drug used widely in autoimmune disease, but has also been employed for the treatment of malaria,1 where it is reported as being half as toxic as the closely-related chloroquine CQ yet equally active against Plasmodium falciparum.2 In UK travel medicine, three drug regimens atovaquone. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. What is the difference between hydroxychloroquine and chloroquine Chloroquine and hydroxychloroquine as available weapons to., Chloroquine and Hydroxychloroquine Toxicity Practice. Chloroquine lysosomal inhibitor sigmaPlaquenil side effects heartPlaquenil and methylprednisolone Retinal abnormalities or new vision problems including the inability to distinguish between colors can indicate toxicity and should be discussed immediately with the consulting ophthalmologist. Hydroxychloroquine use in children younger than 7 may be limited by the difficulty in obtaining satisfactory evaluation of color vision in this age group. Drug spotlight on hydroxychloroquine Lupus Foundation of.. Hydroxychloroquine is much less active than chloroquine.. Difference between chloroquine and hydroxychloroquine.. Chloroquine and hydroxychloroquine belong to the quinolone family. Although their therapeutic and toxic doses differ, they are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity. The image below depicts hydroxychloroquine retinopathy. What Conditions Does This Treat? Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.