While many of these can be grouped by anatomic location or type of toxicity, there are also individual medications with characteristic effects. In this article, we will describe several major categories of pharmacologic retinal toxicity and discuss examples of individual medications. Chloroquine phosphate fish medication Chloroquine prevention malaria Hydroxychloroquine and skin discoloration Talc, an inert filler used in oral powdered medications, deposits in the arterial system of the lungs and liver when injected systemically. It may also lodge in the macular arterial vasculature, causing a granulomatous reaction with focal occlusion, leading to eventual macular ischemia. Focus on Eyes Long-term Plaquenil intake can affect your vision by Dr. Juan Carlos de Rivero Vaccari and Dr. Frederick Ho, Special to FLORIDA TODAY Plaquenil, or hydroxychloroquine, is an anti-malaria medication that is commonly used to treat autoimmune disorders. What to do When Medications Affect Your Vision BACKGROUND Cystoid macular oedema CMO is an uncommon complication associated with hydroxychloroquine HCQ retinopathy threatening central vision. We report a patient with HCQ retinopathy and CMO, for which an intravitreal dexamethasone implant was used, which led to complete resolution of oedema. Both medications have been shown to bind melanin and to concentrate in the iris, ciliary body and retinal pigment epithelium, altering normal physiologic function. Chloroquine (Aralen) and hydroxychloroquine (Plaquenil) are traditional antimalarial agents now used in the treatment of autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Plaquenil macular edema Pause the Plaquenil?, Plaquenil Macular Degeneration Association Chloroquine anti-malarial drugPlaquenil joint painPlaquenil pigmentation treatment Dec 17, 2019 Macular edema occurs when fluid builds up in the retina—the light sensitive tissue in the back of the eye. This causes swelling and can distort vision. The macula, in the center of the retina, helps us see fine detail and color —it delivers images to us at a higher resolution than any camera or screen. What Is Macular Edema? - American Academy of Ophthalmology. Intravitreal dexamethasone implant therapy for the treatment of cystoid.. Macular Edema Treatment - American Academy of Ophthalmology. The aim of this study is to report a rare case of macular edema as a presentation of hydroxychloroquine-related retinal toxicity. We presented a case of a 46-year-old female patient using hydroxychloroquine for underlying rheumatoid arthritis RA with blurred vision over the left eye. Nov 01, 2015 H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. Aug 29, 2014 Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy.