Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine and breastfeeding Hydroxychloroquine 25mg Plaquenil overdose fatal Bull's eye maculopathy maculopathy, bull's eye An ocular condition in which degeneration of the retinal pigment epithelium in the macular area causes alternating ring-like light and dark zones of pigmentation, as in a target. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Bulleye chloroquin retinopathy Hydroxychloroquine-Induced Retinal Toxicity - American., Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Use of plaquenil for osteoarthritis Autofluorescence can detect even earlier retinopathy before the visual loss. Treatment and medications There is no good way to treat inherited genetic eye conditions that cause Bull’s Eye Maculopathy. Bull's Eye Maculopathy – Causes, Complications, and Treatment.. Chloroquine retinopathy - Wikipedia. Retinal Physician - Hydroxychloroquine Maculopathy An Update.. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these photos. Benign concentric annular macular dystrophy BCAMD is initially characterized by parafoveal hypopigmentation and good visual acuity, but progresses to a retinitis pigmentosa RP-like phenotype with a bull's eye configuration van Lith-Verhoeven et al. 2004. Bull's-eye maculopathy has been associated with various macular diseases, most notably chloroquine and hydroxychloroquine maculopathy, cone dystrophy, and Stargardt disease Table 1. To our knowledge, bull's-eye maculopathy associated with chronic macular holes has not been previously reported.