Long-term progression of hydroxychloroquine retinopathy off the drug marmor

Discussion in 'Chloroquine Phosphate 500 Mg' started by cardinal_gray, 27-Feb-2020.

  1. Miw Guest

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Pham B, et al. Long-term progression of hydroxychloroquine retinopathy off the drug. Presented at Association for Research in Vision and Ophthalmology annual meeting; April 29-May 3, 2018; Honolulu. We found that a pericentral pattern of HCQ retinopathy was predominant among Korean patients, rather than the traditional bull's eye parafoveal pattern of damage. Retinopathy progressed while on the drug, but the progression stopped in patients with toxicity detected before RPE damage. Purpose To characterize the stability or progression of different stages of hydroxychloroquine HCQ retinopathy up to 20 years after stopping the drug. Methods We reviewed findings from 13 patients with initial HCQ retinopathy classified as early patchy photoreceptor damage, moderate ring of photoreceptor thinning or scotoma, or severe retinal pigment epithelial RPE damage.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor

    Chloroquine and Hydroxychloroquine Toxicity Clinical., Pericentral Hydroxychloroquine Retinopathy in Korean Patients

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  3. Oct 30, 2019 Baseline and periodic screening for retinopathy is necessary for rheumatologic uses and in long-term therapy eg, 1 to 5 years depending on patient risk factors AAO Marmor 2016; Travassos 2019. Tolerability GI upset nausea, vomiting, diarrhea is a common adverse effect. Dividing doses, taking with food, and, if appropriate, gradual dose escalation in treating rheumatologic diseases may improve tolerability Wallace 2019.

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    PURPOSE To characterize the stability or progression of different stages of hydroxychloroquine HCQ retinopathy up to 20 years after stopping the drug. METHODS We reviewed findings from 13 patients with initial HCQ retinopathy classified as early patchy photoreceptor damage, moderate ring of photoreceptor thinning or scotoma, or severe retinal pigment epithelial RPE damage. Hydroxychloroquine retinopathy primarily involves outer retina photoreceptors. Outer retinal thinning while using HCQ initially involves the parafovea, but becomes diffuse across the macula as damage progresses or after drug cessation. Mar 15, 2019 Marmor MF, Hu J. Effect of disease stage on progression of hydroxychloroquine retinopathy. JAMA Ophthalmol. 2014 Sep. 132 91105-12. Kellner S, Weinitz S, Farmand G, Kellner U. Cystoid macular oedema and epiretinal membrane formation during progression of chloroquine retinopathy after drug cessation.

     
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  5. fighter2007 New Member

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  6. long3r New Member

    Chloroquine phosphate where to buy it. REEF2REEF Saltwater and Reef. So, I called a bunch of local vets here in the Sacramento area where I live and I can't seem to get any vet to prescribe me Chloroquine phosphate after I explained that they are for marine fish, etc etc. they need me to "bring in the patient/animal" in order to prescribe it. Where the heck can.

    Aquarium Fish Chloroquine A "New" Drug for Treating Fish.