A response has come from China to the respiratory disease caused by the new coronavirus (SARS-Co V-2) that emerged in December 2019 in this country. Indeed, following the very recent publication of results showing the in vitro activity of chloroquine against SARS-Co V-2, data have been reported on the efficacy of this drug in patients with SARS-Co V-2-related pneumonia (named COVID-19) at different levels of severity. Chloroquine rapamacyin Hydroxychloroquine sulfatr interactions Aug 06, 2014 Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Chloroquine retinopathy. May be irreversible. This occurs with long-term use over many years or with high doses. Patients on long-term chloroquine therapy should be screened at baseline and then annually after five years of use. Although it is considered rare, retinal toxicity from the intake of Plaquenil can be irreversible even if the drug is discontinued 2, 3. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin -containing structures in the body. The first results obtained from more than 100 patients showed the superiority of chloroquine compared with treatment of the control group in terms of reduction of exacerbation of pneumonia, duration of symptoms and delay of viral clearance, all in the absence of severe side effects Regarding viruses, for reasons probably partly identical involving alkalinisation by chloroquine of the phagolysosome, several studies have shown the effectiveness of this molecule, including against coronaviruses among which is the severe acute respiratory syndrome (SARS)-associated coronavirus. Thus, following the in vitro results, 20 clinical studies were launched in several Chinese hospitals. Plaquenil retinopathy irreversible How to Succeed in Plaquenil Screenings, Chloroquine - Wikipedia Stopping hydroxychloroquine sulfate tabsChloroquine retroviral transfection Apr 20, 2011 Problems with Plaquenil Use Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. New Plaquenil Guidelines. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors.. Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. SIGNIFICANCE Hydroxychloroquine retinopathy causes irreversible central visual loss and can progress despite medication discontinuation. Appropriate dosing and recognition of early disease are important to minimize adverse visual sequelae. In particular, chloroquine and hydroxychloroquine Plaquenil are two such medications, with the potential for retinal toxicity. Given that the retinal damage from these medications is largely irreversible, screening by a retinal specialist is critical to detect early retinal toxicity to try and limit the extent of visual loss. Hydroxychloroquine HCQ trade name, Plaquenil and chloroquine CQ trade name, Aralen are drugs established in the treatment of autoimmune disease and skin disorders, but are also emerging as a treatment option in oncology and paediatric inflammatory disorders.