The proposed mechanism is inhibition of CYP450 2D6 hepatic metabolism by hydroxychloroquine. In a randomized, double-blind, crossover study, seven healthy subjects with CYP450 2D6 extensive metabolizer phenotypes took 400 mg hydroxychloroquine or placebo twice daily for 8 days, and 100 mg metoprolol orally on the ninth day. Plaquenil helps.me.sleep Chloroquine intercalating Chloroquine phosphate resistant malaria Hydroxychloroquine ears There is a moderate interaction between Metoprolol and Plaquenil. You may want to consider another combination. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice. Metoprolol is a cardiovascular medication. Your medicine may need to be healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. 1. Lopressor metoprolol tartrate US prescribing information. Some of the drugs that can potentially interact with metoprolol tartrate include clonidine, calcium channel blockers, and nonsteroidal anti-inflammatory drugs NSAIDs. Metoprolol Tartrate Interactions An Overview. Metoprolol tartrate Lopressor ® can potentially interact with a number of other medicines. No adverse effects were reported and the clinical significance is unknown. Average metoprolol AUC increased by 65% and maximum plasma concentrations increased by 72%. Can plaquenil and metoprolol tartrate be taken together Metoprolol succinate and Plaquenil drug interactions., Interactions between Plaquenil Oral and selected-cyp2d6. Ocular issue plaquenilHow to make hydroxychloroquine at homeChloroquine eea1Hydroxychloroquine retinopathy mechanismCan hydrocodone and hydroxychloroquine be taken together Research on the web says that Atenolol is much longer lasting than Metoprolol and suggests that Metoprolol Tartrate has to be taken twice a day. Atenolol only once ! Atenolol only once ! Strangle, again, my Cardiologist who issued a prescription for Atenolol upon my request to be allowed to try it is for 25 mg twice a day. Metoprolol and bisoprolol - MedHelp. Drug Interactions With Metoprolol Tartrate. Metoprolol Tartrate Oral Interactions with Other Medication. Drug interactions are reported among people who take Metoprolol tartrate and Plaquenil together. This study is created by eHealthMe based on reports of 288 people who take Metoprolol tartrate and Plaquenil from Food and Drug Administration FDA, and is updated regularly. eHealthMe has been monitoring drugs and supplements since 2008. Nov 08, 2014 The difference is that Metoprolol SUCCINATE slow-releases its dose over a 24-hour period, whereas, Metoprolol TARTRATE releases over a 12-hour period. so you can either take your entire daily dose, as succinate, once a day. or. you can take tartrate twice a day with each dose being half of the total daily milligrams you need. Succinate toprol is the long acting form of metoprolol where as tartrate lopressor is the shorter acting form. Toprol can be taken once a day and Lopressor metoprolol tartrate is usually taken at least twice a day.