Plasmodium species are transmitted by the bite of an infective female mosquito. Occasionally, transmission occurs by blood transfusion, organ transplantation, needle sharing, nosocomially, or from mother to fetus. Plaquenil use during pregnancy Plaquenil cause cushings Chloroquine, or hydroxychloroquine, has been used to treat malaria since 1944. It can be given before exposure to malaria to prevent infection, and it can also be given as treatment afterward. Malaria is a disease that is caused by a parasite, unlike COVID-19. The prevention of malaria. When chloroquine. is used at higher doses for many years, a rare eye condition called retinopathy has occurred. People who take chloroquine for more than five years should get regular eye exams. For more information Check out the CDC malaria website at. Among children 10 years old, 32% of infections with chloroquine-resistant parasites cleared after chloroquine treatment, whereas 66% of older children and young adults showed such clearance. Frequent in vivo clearance of chloroquine-resistant parasites with the K76T mutation also occurred in other studies. Travelers going to malaria-endemic countries are at risk for contracting the disease, and almost all of the approximately 1,700 cases per year of malaria in the United States are imported. Malaria is a major international public health problem; 91 countries reported an estimated 216 million infections and 445,000 deaths in 2016, according to the World Health Organization (WHO) World Malaria Report 2017. Chloroquine resistant malaria Malaria Prophylaxis. The ABCD of Malaria Prophylaxis. Patient, Medicines for the Prevention of Malaria While Traveling. Chloroquine 500 mg dosingPlaquenil and 5hr energy interactionsWhat is the mechanism of action of chloroquinePlaquenil special considerations Chloroquine-resistant P. vivax malaria was first identified in 1989 among Australians living in or traveling to Papua New Guinea. P. vivax resistance to chloroquine has also now been identified in Southeast Asia, Ethiopia, and Madagascar. Isolated reports have suggested chloroquine-resistance P. vivax in other countries and regions, but further evaluation is needed. CDC - Malaria - Malaria Worldwide - How Can Malaria Cases.. Chloroquine-Resistant Malaria The Journal of Infectious.. DRUG RESISTANT MALARIA CURRENT STATUS. Mefloquine is one of the oldest chloroquine-resistant falciparum Malaria pills developed during the Vietnam War. It is taken weekly starting the week before you arrive in the risk area, and for four weeks after leaving the area. However, Mefloquine is not often prescribed by travel doctors because of its side effects. Chloroquine is used extensively in malaria endemic areas in Africa to treat the uncomplicated form of Plasmodium falciparum malaria. However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites. Chloroquine, brand name Aralen, is an anti-malarial drug. It is similar to hydroxychloroquine Plaquenil, and is useful in treating several forms of malaria as well as amebiasis that has spread outside of the intestines.