It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Can plaquenil make psoriatic arthritis worse Chloroquine dna transfection Hydroxychloroquine rheumatoid arthritis How long does it take for plaquenil hydroxychloroquine to work with rashes? Answers Follow Share. How long is it supposed to it take for plaquenil hydroxychloroquine to get rid of the lupus butterfly rash? 1 doctor responded I had a skin rash from plaquenil hydroxychloroquine. I was put on a 21 day taper of prednisone. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Ok I'll admit I'm impatient to feel better and get on with my life. My question is, how long does it take for plaquenil to make an impact? And does it really help the fatigue? That's my biggest issue. I've been on it for about three and a half weeks. Thanks! Danni Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. How long does plaquenil take to work Plaquenil Oral Uses, Side Effects, Interactions, Pictures., Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Chloroquine and proguanil Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine Side Effects, Dosage, Uses, and More. When does the plaquenil kick in? DailyStrength. Hydroxychloroquine Plaquenil -. My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? I know I've read it can take up to 6 months but what I'm wondering is, do you just wake up one day and find it's kicked in 6 months down the road or more likely, it starts to work slowly over 6 months? Damage to the retina, the light sensitive portion of the inner eye, can occur with long-term use of Plaquenil or chloroquine Aralen. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. Flesh colored itchy rash on top of feet and inside ankle. I do take plaquenil hydroxychloroquine 400mg daily fo more Flesh colored itchy rash on top of feet and inside ankle. I do take plaquenil hydroxychloroquine 400mg daily for ra. Havent changed soaps, detergents, etc.