We were much later told that the Plaquenil had "lowered his tolerance to infection, as it is also an immuno-suppressant." In essence, the medicine allowed the viral infection to cross the barrier between his brain and blood/lungs. His/our question is as to whether he can or should EVER go back on the medication and risk exposure to further illnesses if it is true that Plaquenil or the generic for is, in fact, an immuno-suppressant and presents a serious health risk for him? Hydroxychloroquine method of action Can plaquenil cause inflammation in my respiratory system Plaquenil is effective for Lupus patients, as well as people with UCTD described to me by a rheumatologist as "Lupus-like" or "Lupus-lite" or "mild Lupus". So it's very possible to be on Plaquenil without having a formal Lupus diagnosis. To get a Lupus diganosis you need to have 4 or more of 11 Lupus criteria, within a 5 year period. I've been on plaquenil for 6 months for suspected Sjogren's syndrome I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil. Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things. Plaquenil damps down the reactiveness of the receptors that send out your “fighters”, which in us is overactive. Rather than strangling the life out of your immune system like steroid meds do, it attenuates the function to closer to normal. We've been told that his 'count' (900 cells per 1,000) was the highest infection level in the spinal fluid that the doctors had ever seen. All the patients they'd encountered w/lower levels had died. (He was never told of that risk when he was put on the medication.) Added : What I failed to mention (above) is that he almost died in April when this happened. Stop antibodies drug plaquenil Medications used to treat lupus Lupus Foundation of America, Hydroxychloroquine plaquenil withdrawl? - LUPUS UK What is hydroxychloroquine made ofChloroquine diphophate salt Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Plaquenil Uses, Dosage & Side Effects -. Stopping Plaquenil - General Discussion - Life With Lupus. Stopping Plaquenil and Cellcept when on Antibiotics. TNF inhibitors are drugs that help stop inflammation. They're used to treat diseases like rheumatoid arthritis RA, juvenile arthritis, psoriatic arthritis, plaque psoriasis, ankylosing spondylitis, ulcerative colitis UC, and Crohn's disease. They're also called TNF blockers, biologic therapies, or anti-TNF drugs. When phenothiazine medications, certain beta blockers, or certain parasite medicines are taken together with Plaquenil, interactions can occur that may affect the drug levels in your blood. This could increase your risk for side effects or decrease the effectiveness of the medicines. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.