In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Teva-chloroquine phosphate Chloroquine phosphate wrasse Skin figure 1A,B. There was no pigmentation at other body sites. Biopsy from the plaque showed necrobiotic collagen with intradermal mucin and perivascular lymphohistiocytic infiltrate accom-panied by brown coarse pigment in the dermis figure 1C,D. The pigment was negative on Perl’s stain figure 1E. This was a unique pattern of Microscopic examination shows yellow- to brown-colored pigment granules in macrophages and fibroblasts and among collagen fibers47, 49; the pigment granules react for iron and some of them for melanin.15, 47 In 2 cases of hydroxychloroquine-associated skin pigmentation, only melanin was identified, 51 and in another 5 cases, melanin and ferric iron 6 were observed. We report two cases of hydroxychloroquine‐induced hyperpigmentation presenting in a 50‐year‐old Caucasian female case 1 and a 78‐year‐old female case 2, both receiving 400 mg per day. Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4–5 years. Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine-induced pigmentation Persistent cutaneous hyperpigmentation due to hydroxychloroquinone one., Drug-associated hyperpigmentation of the oral mucosa report of four. Hydroxychloroquine and neutropeniaRaynauds and hydroxychloroquinePlaquenil ff erg severePlaquenil wonder drug Drug-induced pigmentation is not generally associated with any systemic toxicity and thus has an excellent prognosis. With some exceptions, pigmentation is usually reversible and slowly fades with discontinuation of the drug. Drug-Induced Pigmentation Background, Pathophysiology, Etiology. Hydroxychloroquine‐induced hyperpigmentation the staining.. Hydroxychloroquine-induced hyperpigmentation A case report Request PDF. Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Conclusions HCQ-induced pigmentation is considered uncommon adverse effect of HCQ, with a prevalence rate of 49.2% indicated in this study. Furthermore, history of bruising, sun exposure, and the presence of mucous membrane pigmentation are possible predisposing factors.