I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Would chloroquine in a sickle cell patient be harmful Give the synthesis of chloroquine What to do if you forget to take your Plaquenil. If you miss a dose of Plaquenil, do not make it up or double your next dose. Wait until the next scheduled time, and take your usual dose. What do you do if Plaquenil does not work? After several months your doctor will check your joints for swelling and see how you feel. If you still have pain. If you feel like your central vision is getting blurred, if you lose the ability to see a digital clock, if you lose color vision—if reds look kind of washed out—or if you have trouble seeing at night Those are early signs that you might be developing Plaquenil retinopathy,” says Katz. Weaning failure is reported only by a few people who take Plaquenil. We study 48,911 people who have side effects while taking Plaquenil from Food and Drug Administration FDA. Among them, 1 has Weaning failure. Find out below who they are, when they have Weaning failure and more. eHealthMe has been monitoring drugs since 2008. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. Do you have to be weaned off of plaquenil Hydroxychloroquine Oral Route Precautions - Mayo Clinic, Protecting your eyesight when taking Plaquenil Lupus. Stopped my plaquenil now having muscle spasms If you really need to get off it, I would taper down slowly, very slowly. There is a similar posting on Healthunlocked, "Why oh why did u stop taking plaquenil." You may want to check it out. I do go for intense eye examinations every 6 months to see if there is a difference in my eyesight from my base examine. I do have SJS also. Hydroxychloroquine plaquenil withdrawl? - LUPUS UK. Will you have Weaning failure with Plaquenil - eHealthMe. Going off Plaquenil - Sclero Forums MAIN - Sclero Forums. Methotrexate strong. You were weaned off Plaquenil hydroxychloroquine and started on methotrexate. Your therapy has been escalated. The Methotrexate is working and that is good. Your doctor will be involved with you for your connective tissue disorder for a long time. Hope this helps. For other types of immunosuppressants, it is safe to stop abruptly if that is what the patient and clinician have decided together. However, more often than not they are weaned if they have helped and stopped abruptly if they weren't helping at all or were associated with side effects. Hi everybody! I recently went to the doc and he recommended that I try cutting my Plaquenil in half from 400mg to 200mg/day. I have been on it since March, 2002. It's been about a week and I have noticed a few slight changes, mainly a little stiffness in my fingers and feeling a little fatigued.