I just got some of my labs back and my C3 and C4 are both really low. I haven't gotten my total complement levels back yet. Plaquenil and lichen planus What happens if you stop plaquenil Is hydroxychloroquine sulfate a sulfa drug Plaquenil and cns I have SLE and have been taking Plaquenil for almost 2 years with ok results for the most part. When I first started on it, I was initially diagnosed with UCTD I am ANA negative but C3 & C4 Complements were borderline low/normal, however last September the Dr. formally diagnosed as SLE. The Plaquenil was successful The complement system consists of 11 components which together form some 10% of circulating plasma protein. The association between the complement system and SLE is contradictory 3,4. The complement system has long been known to be activated in exacerbations of SLE, particularly reflecting nephritic activity 5,6,7. It Study Finds Blood Levels of Plaquenil may be Important Indicator of Eye Disease Risk New research finds that measuring blood levels of the medication hydroxychloroquine Plaquenil in people with lupus may be an effective way to predict risk of retinopathy, a disease which results in impaired or complete loss of vision. I have pain in almost all my joints and it seems to be more ligament and tendon pain than bone pain. keepnitreel, I have had tendonitis and tenosynovitis off and on for about 7 years so I can sympathize with you. I was reading on line that it suggests renal disease but my GFR has improved and there is no protein in my urine, unlike some of my other previous urine samples. I know I've entered into a flare and I have had low complements before, but I've been in much worse flares and my complements didn't fall. Also, does anyone know about or have tendon and ligament problems? Plaquenil and complement levels Complement levels lupus - reddit, Serum Complement C3 and C4 Levels in Relation to Diagnosis of. Hydroxychloroquine lyme treatmentChloroquine ready made solutionPlaquenil twitchingChloroquine and malaria prophylaxis Plaquenil makes a very nice complement to minocycline. However, before starting it, be sure to check for side-effects and other drug-interactions with anything else you may be taking. I’ve used plaquenil twice and both times had to stop it after five monthsfirst time for optical migraines and second time for really severe gastrointestinal gas. Mixing Mino with Plaquenil? - Road Back Foundation. Study Finds Blood Levels of Plaquenil may be Important.. Necessary Tests Lupus, Levels of Complement Proteins and.. Results showed that the rate for incident proteinuria was significantly lower in older patients and among Caucasian patients. Also, very low levels of complement 3 C3 and complement 4 C4 — a hallmark of lupus — and high levels of autoantibodies, such as anti-dsDNA, associated with incident proteinuria. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. A lower dose may stop them. Do not lower the dose on your own. Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. You should have an eye examination every year to prevent a very rare but serious eye problem.