Assay of chloroquine phosphate

Discussion in 'Discount Prescriptions' started by ruslik48rus, 14-Mar-2020.

  1. Flaviy Moderator

    Assay of chloroquine phosphate


    Different types of Articles, Analytical Method, Manufacturing Formulation & Pharma Guidelines. Dissolve the residue by adding sufficient (1-2 ml) 3N hydrochloric acid drop-wise, to achieve complete solution.

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    In vitro. Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. In most cases, 250 mg tablets have an equivalence of 150 mg chloroquine base, and 500 mg tablets have an equivalence of 300 mg chloroquine base. Although the purity mentioned above is generally accurate, it would be best to verify the chloroquine base contained in the tablets of your choice in order to be able to properly calculate the exact dosage. Weigh and powder 20 tablets. Dissolve a quantity of powder equivalent to 250 mg of Chloroquine Phosphate in 10 ml of M Sodium Hydroxide and extract with four 25 ml quantities of chloroform. Combine the chloroform extracts and evaporate to a volume of about 10 ml. Add 40 ml of anhydrous acetic acid and carry out non aqueous titration, determining the end point potetiometrically.

    Add 8 ml of 5M Sodium Hydroxide Take sample equivalent to 200 mg of Calcium Pantothenate in a 250 ml titration flask. Then dilute with water to 150ml, add 15ml of 1N sodium hydroxide and 3-5 mg of Hydroxy naphthol blue as indicator and titrate with 0.05M Edetatedisodium VS until the solution is deep blue.1 ml 0.05M Edetate disodium Dissolve a quantity of the powder containing 0.300 g of Calcium Lactate Pentahydrate in 50 ml of water and titrate with 0.05 M Disodium Edetate VS to within a few milliliters of the expected end point.

    Assay of chloroquine phosphate

    CHLOROQUINE PHOSPHATE, USP, Chloroquine phosphate REEF2REEF Saltwater and Reef.

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  7. Assay— Dissolve about 100mg of Chloroquine Phosphate,accurately weighed,in about 5mLof water,and dilute quantitatively and stepwise with dilute hydrochloric acid 1in 1000to obtain a solution containing about 10µg per mL. Similarly prepare a Standard solution of USP Chloroquine Phosphate RS. Concomitantly determine the absorbances of both solutions in 1-cm cells at the wavelength of maximum.

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    On the analysis of chloroquine phosphate was investigated. This was carried out by accurately weighing aquantity of each excipent equivalent to the concentration in 100 mg chloroquine phosphate in the formulation in 100 ml volumetric flask and diluting to volume with water. Five ml of this solution were accurately transefered to 100 Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Is chloroquine a cure for coronavirus? Some scientists are touting the efficacy of the drug in preliminary studies, but are also noting that much more research needs to be done before confirming.

     
  8. PokerOnline Guest

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  9. Morituri XenForo Moderator

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  10. Murlo User

    Plaquenil Hydroxychloroquine for Lupus - LupusCorner Plaquenil is sold in 200mg tablets. The recommended adult dosage for a person with lupus is 200 to 400 mg daily. It can be taken in two doses or at one time. Doses above 400 mg/day are not recommended.

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    Hydroxychloroquine Indications, Side Effects, Warnings.