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Cymbalta offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. ; Eli Lilly and Co.) is classified as a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It was approved by the Food and Drug Administration (FDA) in August 2004 for the treatment of major depressive disorder (MDD) and one month later received an indication for the treatment of peripheral neuropathic pain associated with diabetic neuropathy (DN). MDD is characterized by a depressed mood or loss of interest in activities for a minimum of 2 weeks. At least four other symptoms must be experienced by the patient and may include fatigue, change in sleep patterns or appetite, impaired concentration, feelings of guilt, or periodic thoughts of death or suicide. 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For example, the patent on the blockbuster antidepressant Cymbalta duloxetine, which costs about $8.66 per 30-milligram capsule, expired in December 2013. Return to Pharmacotherapy Update Index. Introduction. Duloxetine Cymbalta ®; Eli Lilly and Co. is classified as a selective serotonin and. Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. 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