Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Plaquenil patient assistance application Plaquenil preeclempsis antiphospholipid Does quinine and chloroquine treat plasmodium organisms Since chloroquine is an 'old' drug, repurposing it to help breast cancer patients should also be very cost effective." Hydroxychloroquine inhibits autophagy, a prosurvival process that breast cancer cells induce and that antiestrogens can stimulate. Whether interfering with this process can enhance breast cancer therapy remains unknown. There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers. While there is considerable evidence for the efficacy and. Autophagy is a process that delivers cytoplasmic components to lysosomes for degradation. This Review discusses clinical interventions to target autophagy in cancer and explains how understanding. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine breast cancer Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on., Frontiers Re-purposing Chloroquine for Glioblastoma Potential Merits. Chloroquine storage temp Autophagy-addicted breast cancers killed by anti-malaria drug, chloroquine by University of Colorado Denver The process of autophagy cleans cells – they wrap up the bad stuff and then dispose of it. Autophagy-addicted breast cancers killed by anti-malaria drug, chloroquine. Targeting autophagy in cancer Nature Reviews Cancer. The Chloroquine Story in Cancer Continues In the Pipeline. Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. At the Methodist Hospital Cancer Center in Houston, medical oncologist Jenny Chang is leading a phase II trial investigating whether chloroquine improves the effects of chemotherapy in metastatic breast cancer patients for whom treatment with anthracyclines failed. Blood-pressure Medications Chloroquine CQ is a 4-aminoquinoline drug used for the treatment of diverse diseases. It inhibits lysosomal acidification and therefore prevents autophagy by blocking autophagosome fusion and degradation. In cancer treatment, CQ is often used in combination.