Chloroquine concentration lysosome

Discussion in 'Health Canada Drug Database' started by dnci, 10-Mar-2020.

  1. dkameleon Moderator

    Chloroquine concentration lysosome


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus. Application DNA intercalator. Also used to increase transfection efficiency. Chloroquine diphosphate salt has been used • in in vitro antiplasmodial assays Results When isolated rat liver lysosomes are incubated with chloroquine it accumulates in the sucroseimpermeable space of the organelles, and the extent of the accumulation is dependent on the concentration of chloroquine in the medium. Chloroquine is a lysosomotropic weak base, which in the monoprotonated form diffuses into the lysosome, where it becomes diprotonated and becomes trapped. Protonated chloroquine then changes the lysosomal pH, thereby inhibiting autophagic degradation in the lysosomes 27.

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine concentration lysosome

    PLOS ONE Chloroquine Is a Zinc Ionophore, Chloroquine accumulation in isolated rat liver lysosomes - ScienceDirect

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  7. Chloroquine is also a lysosomotropic agent, meaning it accumulates preferentially in the lysosomes of cells in the body. The pK a for the quinoline nitrogen of chloroquine is 8.5, meaning it is about 10% deprotonated at physiological pH as calculated by the Henderson-Hasselbalch equation.

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    Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Autophagy is involved in the pathophysiology of numerous diseases and its modulation is beneficial for the outcome of numerous specific diseases. In terms of other drugs, concurrent use of chloroquine increases the plasma concentration of digitoxin a cardiac glycoside fourfold 55. Hence, levels of digitoxin require close monitoring during. The unprotonated form of chloroquine diffuses spontaneously and rapidly across the membranes of cells and organelles to acidic cytoplasmic vesicles such as endosomes, lysosomes, or Golgi vesicles and thereby increases their pH Al‐Bari 2015.

     
  8. Roman_SPB XenForo Moderator

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Requip Ropinirole Side Effects & Adverse Reactions List. Ropinirole Side Effects, Dosage, Uses, and More Requip Ropinrole - Parkinson's News Today
     
  9. Patternes New Member

    Recommendations on Screening for Chloroquine and. Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been.

    Hydroxychloroquine and Chloroquine Retinopathy.
     
  10. spa XenForo Moderator

    Chloroquine Resistance in Plasmodium falciparum - microbewiki Development of Chloroquine Resistance in Plasmodium falciparum. Drug resistance is the ability of a parasite to survive despite the presence of a drug that is meant to kill it in toxic levels. Resistance developed by most parasites that were initially sensitive to drugs mostly result from mutations in the genes responsive to the drug.

    Localized permanent epidemics the genesis of chloroquine.