Indeed, the ability to salvage nucleotides from sources within the body alleviates any significant nutritional requirement for nucleotides, thus the purine and pyrimidine bases are not required in the diet. The salvage pathways are a major source of nucleotides for synthesis of DNA, RNA and enzyme co-factors. Chloroquine lysosome acidification Chloroquine dose per kg Abstract. 1 Chloroquine, primaquine and ethidium inhibitied thymidine incorporation into deoxyribonucleic acid of rat tissues when administered concurrently with the labelled precursor. 2 Chloroquine and primaquine inhibited the incorporation of uridine and adenine, but not orotate, into various ribonucleic acid fractions of liver of rats and mice. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Nucleic acid metabolism DNA metabolism. Replication, repair, and recombination—the three main processes of DNA metabolism—are carried out by specialized machinery within the cell. DNA must be replicated accurately in order to ensure the integrity of the genetic code. Errors that creep in during replication or because of damage after replication must be repaired. Following their synthesis in the liver the nucleotides are dephosphorylated and in part phosphorolytically cleaved into nucleobases and ribose-1-phosphate for transport to the blood and then subsequent uptake by cells of the other organs. Within the body the major site of de novo nucleotide synthesis, for the replenishment and maintenace of intracellular pools, is the liver. Chloroquine nuclei acid biosynthesis Diseases due to Errors in Nucleic Acid Metabolism, Chloroquine - Wikipedia Chloroquine tinnitusPlaquenil itching side effectsChloroquine base lethal doseCheap aralen phosphateArthritis medicine plaquenil Download Citation Differential effects of chloroquine on cardiolipin biosynthesis in hepatocytes and H9c2 cardiac cells Chloroquine is a potent lysomotropic therapeutic agent used in the. Differential effects of chloroquine on cardiolipin.. Nucleic acid - Nucleic acid metabolism Britannica. Plasmodium falciparum Nucleic acid and pigment changes in.. Reactions of quinine, chloroquine, and quinacrine with DNA and their effects on the DNA and. The influence of antimalarial drugs on nucleic acid synthesis in Plasmodium gallinaceum and Plasmodium berghei. Biochem Pharmacol. PARKER FS, IRVIN JL. The interaction of chloroquine with nucleic acids and nucleoproteins. J Biol Chem. 1952 Dec; 199 Addition of chloroquine to the incubation mixture, at a concentration of 1 or 10 mM, resulted in a significant inhibition of the nucleic acids and protein synthesis. Therefore, this effect on retinal nucleic acid and protein synthesis may be important in the pathogenesis of retinal disease observed during chloroquine therapy. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin.