Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Sjogren's i can't tolerate plaquenil Vertigo from plaquenil Cyclosporine and plaquenil Macular Society Eye screening for patients taking hydroxychloroquine. Hydroxychloroquine is a medication used to treat several conditions including rheumatoid arthritis, systemic lupus erythematosus, some skin conditions especially photosensitive ones and others that involve inflammation. A repeat of that exam should occur every year IF there is no evidence of toxicity. The actual incidence of retinal toxicity from hydroxychloroquine is difficult to pin down because there is usually a long time between being started on the drug and the start of any identifiable retinal toxicity. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Hydroxychloroquine toxicity eye exam Focus on Eyes Long-term Plaquenil intake can affect your vision, What can Hydroxychloroquine Plaquenil do to my eyes? Best time to take plaquenilHow does chloroquine phosphate work Thus, the possibility of toxicity should not be disregarded and close monitoring of the ocular findings is required. As a precaution, patients treated with Plaquenil are advised to get a baseline eye exam prior to starting the drug and then annually thereafter The Risk of Retinal Toxicity with Plaquenil. Hydroxychloroquine Plaquenil Toxicity and Recommendations for Screening. Hydroxychloroquine-Induced Retinal Toxicity - American Academy of.. Hydroxychloroquine And Chloroquine Screening 2016 AAO Recommendations The American Academy of Ophthalmology released an updated set of screening recommendations for hydroxychloroquine Plaquenil and chloroquine to account for the many studies that have shown the effects of these medications on the retina 1. Of cells at the back of the eye. This is known as retinal toxicity or retinopathy. Overall, around seven patients out of every 100 taking hydroxychloroquine for more than five years may develop retinopathy that can be detected with specialised tests. The risk is much higher in patients who have been taking the drug for 20 years or more. In these Mar 29, 2012 Plaquenil hydroxychloroquine used for lupus and rheumatoid arthritis can cause toxicity to the retina leading to vision loss. In this episode of A State of Sight, Isaac Porter, MD explains how.