Chloroquine autophagy concentration

Discussion in 'Hydroxychloroquine Plaquenil' started by ally_lay, 02-Mar-2020.

  1. bigbadaboom XenForo Moderator

    Chloroquine autophagy concentration


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    Chloroquine is a well-characterized drug that has been used successfully for prophylaxis and treatment of malaria. Chloroquine increases the pH of cellular lysosomes by disrupting the proton pump mechanism, raising the lysosomal pH by approximately 0.5–1.5. Tumor cells require autophagy to remove misfolded proteins or damaged cellular organelles. SBI-0206965 was shown to suppress autophagy induced by mTOR inhibition. mTOR signaling is often hyperactive in many tumors and can drive proliferation, so mTOR inhibitors are being investigated as anticancer agents. When added separately, chloroquine or high concentrations of bafilomycin A1 ≥10 nM induced a dose-dependent inhibition of autophagy as measured by an increase in LC3-II, a marker specific for autophagosomes, followed by caspase-3 activation and cell death.

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine autophagy concentration

    Inhibition of autophagy with bafilomycin and chloroquine., Autophagy Inhibitors - Autophagy Sigma-Aldrich

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  7. Chloroquine CQ is a lysosomotropic agent with an extensive range of biological effects 1. Historically known for its anti-malarial activity, chloroquine is a widely used biological research tool for studying autophagy inhibition. Research studies demonstrate that chloroquine accumulates in acidic lysosomes and increases the lysosomal pH.

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    Nov 15, 2015 Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4. Chloroquine cQ is an antimalarial drug and late-stage inhibitor of autophagy currently FDA-approved for use in the treatment of rheumatoid arthritis and other autoimmune diseases. Based primarily on its ability to inhibit autophagy, c Q A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen.

     
  8. seodobriy XenForo Moderator

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  9. phoenix05 XenForo Moderator

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