To date, it was assumed that chloroquine increases the sensitivity of cancer cells to chemotherapy by means of a direct effect on the cancer cells. However, a recent study has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors. Chloroquine induced cardiomyopathy What are the rates of plaquenil Hydroxychloroquine sulfate pharmacological class Plaquenil and blood pressure The antimalarial drugs chloroquine CQ and hydroxychloroquine HCQ have potential applications in cancer treatment. The growth of MCF-7 and MDA-MB-231 human breast cancer cells in vitro was inhibited by CQ and HCQ and these cells were more sensitive than nontumorigenic MCF-10A breast epithelial cells. Chloroquine prevented DCIS xenografts' outgrowth in athymic mice and inhibited N-methyl-N-nitrosurea–induced mammary carcinogenesis, suggesting chloroquine-based therapy as a possible agent in the prevention of initial premalignant lesions from progressing to breast cancer. Breast Cancer. The first evidence of how genetic inactivation of autophagy can contribute to the malignant transformation in breast cancer was made by Liang and colleagues in 1999. They showed that Beclin1 expression is frequently low in human breast epithelial carcinoma cell lines and tissues, but expressed at high levels in normal breast epithelia. The anti-cancer effect of the antimalarial agent chloroquine when combined with conventional chemotherapy has been well documented in experimental animal models. This blood vessel normalization results in an increased barrier function on the one hand, and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy. Chloroquine and breast cancer Chloroquine sensitizes breast cancer cells to chemotherapy., Chloroquine Inhibits Autophagy to Potentiate Antiestrogen. Metformin versus hydroxychloroquine for tyle 2 diabetesAllergic to plaquenil what else can i take In fact, the researchers believe that chloroquine stands a good chance as a routine drug taken by women on a yearly basis to prevent breast cancer. That, of course, will only happen after a long series of clinical trials. The PINC trial joins two other clinical trials involving breast cancer led by George Mason researchers. Anti-malaria Drug Quinine Heads the List of Breast Cancer.. Autophagy Modulation in Cancer Current Knowledge on Action and Therapy. Frontiers Re-purposing Chloroquine for Glioblastoma Potential Merits.. Chloroquine is an antimalaria drug that also suppresses tumor growth and metastasis. Chloroquine neutralizes the pH of intracellular compartments, thereby disrupting the endosomal trafficking and lysosomal function. Whereas chloroquine impairs autophagy and proliferation in tumor cells, Maes et al. found that chloroquine suppressed the growth and metastasis of melanoma by acting on tumor. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Autophagy is one way of killing cancer cells, which brings the story of chloroquine to the treatment of breast cancer. Many forms of breast cancer begin with pre-cursor cells, anomalous cells among the normal fat and tissue cells of the breast.